Protein coding gene MELO3C006188
Accession: MELO3C006188
Name: MELO3C006188
Description: Similar to ATP-dependent DNA helicase 2 subunit KU80 (Arabidopsis thaliana) (uniprot_sprot:sp|Q9FQ09|KU80_ARATH)
Properties
These properties come from blast2go analysis
molecular_function: ATP-dependent DNA helicase activity, DNA binding.
cellular_component: nucleus.
biological_process: double-strand break repair via nonhomologous end joining.
These properties come from reactome analysis
REACTOME_REACTION: Removal of 3-phosphoglycolate (PG) moiety from DSB ends (REACT_6774), Removal of repair proteins and ligation of the processed ends of the DNA double-strand break (REACT_12), Association of Ku heterodimer with ends of DNA double-strand break (REACT_104166), Association of XRCC4:DNA ligase IV complex with viral DNA ends (REACT_9042), Association of Ku heterodimer with ends of DNA double-strand break (REACT_107119), 2-LTR formation due to circularization of viral DNA (REACT_9073), Association of Ku heterodimer with ends of DNA double-strand break (REACT_1854), Synapsis, or interaction between two DNA-PK:DNA complexes at opposing ends of DNA DSB (REACT_1971), Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks (REACT_1989), Removal of 3-phosphate moiety from DSB ends (REACT_6746), Association of Ku heterodimer with ends of DNA double-strand break (REACT_96293), Association of the XRCC4:DNA ligase IV complex with the DNA-PK:DNA synaptic complex (REACT_657), Association of Ku heterodimer with viral DNA ends (REACT_9022).
biological_process: viral reproduction, DNA repair, double-strand break repair, initiation of viral infection, provirus integration, double-strand break repair via nonhomologous end joining.
REACTOME_COMPLEX: DNA-PK:DNA complex [nucleoplasm] (REACT_2311), DNA-PK:DNA synaptic complex with ligatable ends [nucleoplasm] (REACT_2405), Ku proteins bound to viral DNA [nucleoplasm] (REACT_7016), Ku:DNA double-strand break ends [nucleoplasm] (REACT_5272), DNA-PK:XRCC4:DNA ligase IV:DNA complex associated with ligatable DNA ends [nucleoplasm] (REACT_2526), DNA-PK synaptic complex [nucleoplasm] (REACT_5513), viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm] (REACT_9308), Ku70:Ku80 heterodimer [nucleoplasm] (REACT_3482).
REACTOME_PATHWAY: Double-Strand Break Repair (REACT_30484), DNA Repair (REACT_107446), Integration of provirus (REACT_6918), Nonhomologous End-joining (NHEJ) (REACT_108116), DNA Repair (REACT_91442), Double-Strand Break Repair (REACT_97002), Nonhomologous End-joining (NHEJ) (REACT_1022), HIV Life Cycle (REACT_6256), Processing of DNA ends prior to end rejoining (REACT_1201), Nonhomologous End-joining (NHEJ) (REACT_108059), Early Phase of HIV Life Cycle (REACT_6266), Double-Strand Break Repair (REACT_2054), Nonhomologous End-joining (NHEJ) (REACT_110441), DNA Repair (REACT_82907), HIV Infection (REACT_6185), DNA Repair (REACT_216), Double-Strand Break Repair (REACT_33123), 2-LTR circle formation (REACT_9058).
These properties come from phylome analysis
molecular_function: telomeric DNA binding, promoter binding, protein C-terminus binding, ATP binding, protein binding, double-stranded DNA binding, ATP-dependent DNA helicase activity, DNA binding.
cellular_component: nonhomologous end joining complex, Ku70:Ku80 complex, cytoplasm, nucleoplasm, nuclear telomere cap complex, nucleus.
biological_process: negative regulation of transcription, DNA-dependent, growth, initiation of viral infection, provirus integration, DNA integration, response to heat, transcription, DNA-dependent, DNA recombination, telomere maintenance, double-strand break repair via nonhomologous end joining.
These properties come from kegg analysis
KEGG_ORTHOLOGS: ATP-dependent DNA helicase 2 subunit 2 (K10885).
KEGG_MODULE: DNA-PK complex (M00297).
