Protein coding gene MELO3C006292
Accession: MELO3C006292
Name: MELO3C006292
Description: Similar to DNA repair protein RAD50 (Arabidopsis thaliana) (uniprot_sprot:sp|Q9SL02|RAD50_ARATH)
Properties
These properties come from blast2go analysis
molecular_function: zinc ion binding, ATP binding, protein binding, nuclease activity.
cellular_component: Mre11 complex, membrane.
biological_process: vesicle-mediated transport, DNA repair.
These properties come from reactome analysis
biological_process: double-strand break repair, double-strand break repair via homologous recombination, DNA repair.
REACTOME_REACTION: Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction (REACT_90379), Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction (REACT_86861), Association of RAD50:MRE11 complex with NBS1 via MRE11 interaction (REACT_730), Association of MRN with sites of DSB (REACT_82130), Formation of RAD50:MRE11 complex (REACT_100315), Formation of RAD50:MRE11 complex (REACT_516), Association of MRN with sites of DSB (REACT_1232), Association of MRN with sites of DSB (REACT_102884), Formation of RAD50:MRE11 complex (REACT_34501), Formation of RAD50:MRE11 complex (REACT_99776).
REACTOME_COMPLEX: MRN:CtIP Complex [nucleoplasm] (REACT_27850), MRX:SAE2 Complex [nucleoplasm] (REACT_27854), MRE11:RAD50:XRS2/NBS1 Complex [nucleoplasm] (REACT_27720), RAD50:MRE11 complex [nucleoplasm] (REACT_5426), DNA double-strand break ends: MRN complex [nucleoplasm] (REACT_3443), MRE11:RAD50:NBS1 complex [nucleoplasm] (REACT_4350).
REACTOME_PATHWAY: Double-Strand Break Repair (REACT_30484), Homologous Recombination Repair (REACT_33853), Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks (REACT_98075), Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks (REACT_486), DNA Repair (REACT_107446), Recruitment of repair and signaling proteins to double-strand breaks (REACT_81901), Recruitment of repair and signaling proteins to double-strand breaks (REACT_92672), MRN complex relocalizes to nuclear foci (REACT_85297), Homologous recombination repair of replication-independent double-strand breaks (REACT_1587), MRN complex relocalizes to nuclear foci (REACT_1884), Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks (REACT_106024), MRN complex relocalizes to nuclear foci (REACT_33695), Homologous recombination repair of replication-independent double-strand breaks (REACT_96279), Recruitment of repair and signaling proteins to double-strand breaks (REACT_100532), Homologous recombination repair of replication-independent double-strand breaks (REACT_82234), Homologous recombination repair of replication-independent double-strand breaks (REACT_32319), Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks (REACT_108183), Double-Strand Break Repair (REACT_84402), Homologous Recombination Repair (REACT_108237), Homologous Recombination Repair (REACT_1874), Double-Strand Break Repair (REACT_2054), Recruitment of repair and signaling proteins to double-strand breaks (REACT_97), DNA Repair (REACT_82907), DNA Repair (REACT_93704), DNA Repair (REACT_216), Double-Strand Break Repair (REACT_33123), Homologous Recombination Repair (REACT_92897), MRN complex relocalizes to nuclear foci (REACT_28281).
These properties come from phylome analysis
molecular_function: G-quadruplex DNA binding, single-stranded telomeric DNA binding, protein binding, bridging, ATPase activity, adenylate kinase activity, double-stranded telomeric DNA binding, double-stranded DNA binding, DNA binding, zinc ion binding, ATP binding, protein binding, nuclease activity.
cellular_component: mitochondrion, cytoplasm, nucleoplasm, condensed chromosome, nuclear chromosome, telomeric region, chromosome, telomeric region, Mre11 complex.
biological_process: meiotic chromosome segregation, meiotic DNA double-strand break formation, positive regulation of growth rate, positive regulation of kinase activity, DNA duplex unwinding, negative regulation of endodeoxyribonuclease activity, positive regulation of protein autophosphorylation, telomere capping, embryo development ending in birth or egg hatching, protein localization, reciprocal meiotic recombination, meiosis, telomere maintenance via telomerase, apoptosis, mitotic recombination, double-strand break repair via nonhomologous end joining, double-strand break repair, base-excision repair, double-strand break repair via break-induced replication, double-strand break repair via homologous recombination, telomere maintenance via recombination, meiotic DNA double-strand break processing, regulation of mitotic recombination, DNA repair.
These properties come from kegg analysis
KEGG_ORTHOLOGS: DNA repair protein RAD50 [EC:3.6.-.-] (K10866).
KEGG_MODULE: BRCA1-associated genome surveillance complex (BASC) (M00295), MRX complex (M00292), MRN complex (M00291).
