Protein coding gene MELO3C008414
Accession: MELO3C008414
Name: MELO3C008414
Description: Similar to Putative transcription elongation factor SPT5 homolog 1 (Arabidopsis thaliana) (uniprot_sprot:sp|Q9STN3|SPT51_ARATH)
Properties
These properties come from blast2go analysis
molecular_function: structural constituent of ribosome, transcription elongation regulator activity.
cellular_component: ribosome.
biological_process: positive regulation of transcription elongation from RNA polymerase II promoter, translation.
These properties come from reactome analysis
REACTOME_REACTION: Dissociation of transcript with 5-GMP from GT (REACT_703), Recruitment of elongation factors to form HIV-1 elongation complex (REACT_6275), 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (REACT_6174), Addition of nucleotides leads to HIV-1 transcript elongation (REACT_6278), Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex (REACT_6170), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_108201), Formation of DSIF complex (REACT_1635), Resumption of elongation after recovery from pausing (REACT_1638), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_93493), 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (REACT_1645), Capping complex formation (REACT_91663), Formation of DSIF:NELF:early elongation complex (REACT_981), Abortive termination of early transcription elongation by DSIF:NELF (REACT_989), Abortive termination of early transcription elongation by DSIF:NELF (REACT_87802), Abortive termination of HIV-1 early transcription elongation by DSIF:NELF (REACT_6281), Separation of elongating HIV-1 transcript from template (REACT_6204), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_802), Abortive termination of early transcription elongation by DSIF:NELF (REACT_89590), Abortive termination of elongation after arrest (REACT_98053), Abortive termination of early transcription elongation by DSIF:NELF (REACT_86233), Elongating transcript encounters a lesion in the template (REACT_1138), Formation of the CE:GMP intermediate complex (REACT_92552), Capping complex formation (REACT_2186), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_6250), TFIIS-mediated recovery of elongation from arrest (REACT_102520), Addition of nucleotides leads to transcript elongation (REACT_100466), Methylation of GMP-cap by RNA Methyltransferase (REACT_93915), Abortive termination of HIV-1 elongation after arrest (REACT_6352), Abortive termination of elongation after arrest (REACT_6355), Formation of DSIF:NELF:HIV-1 early elongation complex (REACT_6357), Recruitment of elongation factors to form HIV-1 elongation complex (REACT_6358), Hydrolysis of the 5-end of the nascent transcript by the capping enzyme (REACT_29917), Dissociation of transcript with 5-GMP from GT (REACT_106203), 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (REACT_6214), Hydrolysis of the 5-end of the nascent transcript by the capping enzyme (REACT_85239), Dissociation of transcript with 5-GMP from GT (REACT_90647), Hydrolysis of the 5-end of the nascent transcript by the capping enzyme (REACT_78922), Limited elongation of the HIV-1 transcript (REACT_6192), Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (REACT_6297), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_6295), Formation of DSIF:NELF:early elongation complex (REACT_96991), Formation of the CE:GMP intermediate complex (REACT_101635), Resumption of elongation of HIV-1 transcript after recovery from pausing (REACT_6299), Methylation of GMP-cap by RNA Methyltransferase (REACT_34170), 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (REACT_83561), Recruitment of elongation factors to form elongation complex (REACT_949), 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (REACT_6347), Addition of nucleotides leads to transcript elongation (REACT_751), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_93340), Capping complex formation (REACT_86608), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_103086), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_102861), TFIIS-mediated recovery of elongation from arrest (REACT_6330), Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (REACT_2066), 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (REACT_30549), Resumption of elongation after recovery from pausing (REACT_99936), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_32792), Formation of DSIF complex (REACT_86571), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_423), Capping complex formation (REACT_85029), Abortive termination of elongation after arrest (REACT_95584), DSIF complex binds to RNA Pol II (hypophosphorylated) (REACT_110194), Separation of elongating transcript from template (REACT_34213), Formation of the CE:GMP intermediate complex (REACT_1580), Hydrolysis of the 5-end of the nascent transcript by the capping enzyme (REACT_1368), Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (REACT_6316), Transfer of GMP from the capping enzyme GT site to 5-end of mRNA (REACT_1968), TFIIS-mediated recovery of elongation from arrest (REACT_101748), 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (REACT_234), Hydrolysis of the 5-end of the nascent transcript by the capping enzyme (REACT_81068), Transfer of GMP from the capping enzyme GT site to 5-end of mRNA (REACT_97660), Addition of nucleotides leads to transcript elongation (REACT_107064), Dissociation of transcript with 5-GMP from GT (REACT_101219), Formation of DSIF complex (REACT_32158), Pol II elongation complex moves on the template as transcript elongates (REACT_30038), Resumption of elongation after recovery from pausing (REACT_79713), Resumption of elongation of HIV-1 transcript after recovery from pausing (REACT_6155), Dissociation of transcript with 5-GMP from GT (REACT_30543), Formation of DSIF complex (REACT_77346), Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (REACT_6311), Pol II elongation complex moves on the HIV-1 template as transcript elongates (REACT_6158), Separation of abortive HIV-1 transcript from template (REACT_6159), TFIIS-mediated recovery of elongation from arrest (REACT_1094), Methylation of GMP-cap by RNA Methyltransferase (REACT_404), Capping complex formation (REACT_32400), Separation of elongating transcript from template (REACT_2030), Transfer of GMP from the capping enzyme GT site to 5-end of mRNA (REACT_102473), Methylation of GMP-cap by RNA Methyltransferase (REACT_97945), Formation of the CE:GMP intermediate complex (REACT_90910), 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest (REACT_6254), Separation of elongating transcript from template (REACT_81515), Formation of DSIF complex (REACT_109906), TFIIS-mediated recovery of HIV-1 elongation from arrest (REACT_6252), Transfer of GMP from the capping enzyme GT site to 5-end of mRNA (REACT_95548), SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (REACT_79829), Formation of the CE:GMP intermediate complex (REACT_79193), Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) (REACT_6269), Transfer of GMP from the capping enzyme GT site to 5-end of mRNA (REACT_77279), Pol II elongation complex moves on the template as transcript elongates (REACT_2053), Pol II elongation complex moves on the template as transcript elongates (REACT_30284).
biological_process: viral reproduction, transcription from RNA polymerase II promoter, gene expression, viral transcription, positive regulation of viral transcription, mRNA capping, transcription elongation from RNA polymerase II promoter.
REACTOME_COMPLEX: Elongation complex prior to separation [nucleoplasm] (REACT_5853), Capping complex (with freed 5- GMP) [nucleoplasm] (REACT_4741), CE:Pol II CTD:Spt5 complex [nucleoplasm] (REACT_6491), Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (REACT_2481), Covalent CE:GMP intermediate complex [nucleoplasm] (REACT_2774), DSIF:NELF:early elongation complex [nucleoplasm] (REACT_6594), Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (REACT_6495), Elongation complex [nucleoplasm] (REACT_3511), Capping complex (GpppN..) [nucleoplasm] (REACT_2312), DSIF:NELF:early elongation complex [nucleoplasm] (REACT_4575), HIV-1 elongation complex containing Tat [nucleoplasm] (REACT_6611), Tat-containing elongation complex prior to separation [nucleoplasm] (REACT_6548), Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (REACT_6633), Capping complex (initial) [nucleoplasm] (REACT_4555), RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (REACT_6426), Paused processive elongation complex [nucleoplasm] (REACT_3066), HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (REACT_6467), Aborted elongation complex after arrest [nucleoplasm] (REACT_6654), HIV-1 elongation complex [nucleoplasm] (REACT_6501), phospho-DSIF complex [nucleoplasm] (REACT_6628), HIV-1 paused processive elongation complex [nucleoplasm] (REACT_6459), HIV-1 aborted elongation complex after arrest [nucleoplasm] (REACT_6471), Aborted early elongation complex [nucleoplasm] (REACT_3362), Aborted HIV-1 early elongation complex [nucleoplasm] (REACT_6695), Early elongation complex with separated aborted transcript [nucleoplasm] (REACT_6590), Arrested processive elongation complex [nucleoplasm] (REACT_4675), CE:Pol II CTD:Spt5 complex [nucleoplasm] (REACT_2332), RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (REACT_4417), HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm] (REACT_6602), Processive elongation complex [nucleoplasm] (REACT_3018), HIV-1 arrested processive elongation complex [nucleoplasm] (REACT_6609), DSIF:NELF:early elongation complex after limited nucleotide addition [nucleoplasm] (REACT_6432), Capping complex (hydrolyzed) [nucleoplasm] (REACT_4969), Elongation complex with separated and uncleaved transcript [nucleoplasm] (REACT_5512), Capping complex (intermediate) [nucleoplasm] (REACT_3580), HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm] (REACT_6532), HIV-1 processive elongation complex [nucleoplasm] (REACT_6579), Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (REACT_6536), DSIF complex [nucleoplasm] (REACT_2797), P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm] (REACT_6686), HIV-1 Tat-containing processive elongation complex [nucleoplasm] (REACT_6452), HIV-1 Tat-containing paused processive elongation complex [nucleoplasm] (REACT_6389).
REACTOME_PATHWAY: RNA Pol II CTD phosphorylation and interaction with CE (REACT_975), Formation of the HIV-1 Early Elongation Complex (REACT_6319), RNA Polymerase II Transcription (REACT_99228), HIV-1 Transcription Elongation (REACT_6274), RNA Pol II CTD phosphorylation and interaction with CE (REACT_6237), mRNA Processing (REACT_109337), Transcription of the HIV genome (REACT_6233), Formation and Maturation of mRNA Transcript (REACT_77979), RNA Polymerase II Transcription (REACT_99950), mRNA Processing (REACT_29019), RNA Pol II CTD phosphorylation and interaction with CE (REACT_28314), Formation of RNA Pol II elongation complex (REACT_1845), RNA Pol II CTD phosphorylation and interaction with CE (REACT_30624), mRNA Processing (REACT_1675), Formation of the Early Elongation Complex (REACT_29380), Gene Expression (REACT_105649), mRNA Capping (REACT_85562), RNA Polymerase II Pre-transcription Events (REACT_99660), mRNA Capping (REACT_1470), Transcription (REACT_100899), Transcription (REACT_1788), Pausing and recovery of elongation (REACT_769), Pausing and recovery of elongation (REACT_111024), Formation and Maturation of mRNA Transcript (REACT_92291), mRNA Processing (REACT_90209), Pausing and recovery of elongation (REACT_83577), RNA Polymerase II Pre-transcription Events (REACT_91707), Gene Expression (REACT_71), Gene Expression (REACT_108313), Formation of HIV-1 elongation complex in the absence of HIV-1 Tat (REACT_22201), HIV-1 elongation arrest and recovery (REACT_6259), Elongation arrest and recovery (REACT_91132), RNA Polymerase II Transcription (REACT_1366), Elongation arrest and recovery (REACT_79615), RNA Polymerase II Transcription Elongation (REACT_833), HIV Life Cycle (REACT_6256), Formation of the Early Elongation Complex (REACT_846), mRNA Capping (REACT_85081), Abortive elongation of HIV-1 transcript in the absence of Tat (REACT_6261), Gene Expression (REACT_98256), Formation and Maturation of mRNA Transcript (REACT_96378), Formation of HIV-1 elongation complex containing HIV-1 Tat (REACT_6346), Tat-mediated HIV-1 elongation arrest and recovery (REACT_6344), Pausing and recovery of Tat-mediated HIV-1 elongation (REACT_6143), RNA Polymerase II Transcription (REACT_106213), Formation and Maturation of mRNA Transcript (REACT_2039), Transcription (REACT_34268), RNA Polymerase II Pre-transcription Events (REACT_22107), Transcription (REACT_87991), Tat-mediated elongation of the HIV-1 transcript (REACT_6162), RNA Polymerase II Transcription (REACT_97471), RNA Polymerase II Pre-transcription Events (REACT_82104), Elongation arrest and recovery (REACT_1892), RNA Polymerase II Transcription Elongation (REACT_107633), RNA Polymerase II Transcription Elongation (REACT_81750), mRNA Capping (REACT_93735), HIV Infection (REACT_6185), RNA Pol II CTD phosphorylation and interaction with CE (REACT_33716), Transcription (REACT_93622), Formation of the Early Elongation Complex (REACT_99528), RNA Polymerase II Transcription Elongation (REACT_87946), Gene Expression (REACT_91657), RNA Polymerase II Transcription Elongation (REACT_92836), mRNA Capping (REACT_102770), Formation of the Early Elongation Complex (REACT_97522), Formation of the Early Elongation Complex (REACT_101279), Formation and Maturation of mRNA Transcript (REACT_32779), mRNA Processing (REACT_80866), RNA Polymerase II Pre-transcription Events (REACT_82727), Late Phase of HIV Life Cycle (REACT_6361), Pausing and recovery of HIV-1 elongation (REACT_6244), RNA Pol II CTD phosphorylation and interaction with CE (REACT_90040).
These properties come from phylome analysis
molecular_function: protein heterodimerization activity, enzyme binding, RNA polymerase II transcription elongation factor activity, positive transcription elongation factor activity, negative transcription elongation factor activity, protein binding, catalytic activity, translation elongation factor activity, RNA polymerase I transcription factor activity, structural constituent of ribosome, transcription elongation regulator activity.
cellular_component: DSIF complex, transcription elongation factor complex, mitochondrion, polytene chromosome interband, polytene chromosome puff, nucleoplasm, nucleus, nuclear exosome (RNase complex), ribosome.
biological_process: positive regulation of viral transcription, positive regulation of transcription from RNA polymerase II promoter, retroviral genome replication, hermaphrodite genitalia development, growth, regulation of transcription elongation, DNA-dependent, response to organic substance, embryo development ending in birth or egg hatching, mitotic cell cycle G2/M transition DNA damage checkpoint, mitotic spindle organization, cell cycle, mRNA processing, mRNA capping, transcription elongation from RNA polymerase II promoter, transcription from RNA polymerase I promoter, regulation of transcription from RNA polymerase II promoter, transcription, DNA-dependent, chromatin remodeling, chromatin organization, transcription-coupled nucleotide-excision repair, DNA repair, nematode larval development, negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription elongation from RNA polymerase II promoter, translation.
These properties come from kegg analysis
KEGG_ORTHOLOGS: transcription elongation factor SPT5 (K15172).
