Protein coding gene MELO3C010966
Accession: MELO3C010966
Name: MELO3C010966
Description: Similar to Mitogen-activated protein kinase homolog NTF3 (Nicotiana tabacum) (uniprot_sprot:sp|Q40517|NTF3_TOBAC)
Properties
These properties come from blast2go analysis
molecular_function: ATP binding, protein binding, MAP kinase activity.
biological_process: protein phosphorylation.
These properties come from reactome analysis
REACTOME_REACTION: MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1 (REACT_85146), ERKs are inactivated by protein phosphatase 2A (REACT_12539), Nuclear translocation of phospho-ERK-2 dimer (REACT_487), ERKs are inactivated by dual-specific phosphatases (DUSPs) (REACT_12439), Interaction of p38 MAPK with JLP (REACT_21282), ERK1/2 phosphorylates MSK1 (REACT_12576), Nuclear translocation of phospho-ERK-1 dimer (REACT_1866), MEK1 phosphorylates ERK-1 (REACT_136), Active p38 MAPK phosphorylates MAPKAPK2 or 3 (REACT_21375), Dimerisation of phospho-ERK-2 (REACT_2196), Phosphorylated MAPKs phosphorylate ATF-2 (REACT_6719), Phosphorylation of L1 by ERK (REACT_22099), ERK1/2/5 activate RSK1/2/3 (REACT_12487), Active p38 MAPK phosphorylates MAPKAPK2 or 3 (REACT_28738), MEK1 binds ERK-1 (REACT_1780), p38MAPK phosphorylates MSK1 (REACT_105534), Dimerisation of phospho-ERK-1 (REACT_1289), Activation of p38 MAPK (REACT_75807), Phosphorylation of E proteins by p38 MAPK (REACT_21321), Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (REACT_95261), activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (REACT_91195), MEK2 binds ERK-2 (REACT_495), p38MAPK phosphorylates MSK1 (REACT_12546), Phosphorylation of KSRP by MAP kinase p38 (REACT_24965), ERK1/2 activates ELK1 (REACT_12406), activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (REACT_21395), Phosphorylation of cPLA2 by ERK-2 (REACT_23990), SOS phosphorylation and dissociation (IRS) (REACT_169), Beta-arrestin-1 acts as scaffold for a PAR1 signalling complex (REACT_23781), Dissociation of phospho-ERK-1:MEK1 (REACT_1740), MEK2 phosphorylates ERK-2 (REACT_2247), MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1 (REACT_12032), Dissociation of phospho-ERK-2:MEK2 (REACT_1019), Phosphorylation of MEF2 proteins by p38 (REACT_21276), Phosphorylation by MAPK/ERK (REACT_20562), c-FOS activation by phospho ERK1/2 (REACT_21251), Phosphorylation of cPLA2 by MAPK p38 alpha (REACT_20541), Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3 (REACT_21358), Phosphorylation of UBF-1:rDNA Promoter (REACT_180), SOS phosphorylation and dissociation (SHC) (REACT_1420), AGER binds ERK1/2 (REACT_25020), SOS phosphorylation and dissociation (IRS, Crk) (REACT_26), Activation of MAPK (REACT_20631), Beta-arrestin-2 acts as scaffold for a PAR1 signalling complex (REACT_23960).
biological_process: small GTPase mediated signal transduction, Ras protein signal transduction, stress-activated MAPK cascade, innate immune response, activation of innate immune response, positive regulation of muscle cell differentiation, toll-like receptor 1 signaling pathway, toll-like receptor 2 signaling pathway, toll-like receptor 3 signaling pathway, activation of MAPKK activity, activation of MAPK activity, ERK1 and ERK2 cascade, regulation of sequence-specific DNA binding transcription factor activity, mRNA metabolic process, toll-like receptor signaling pathway, axon guidance, synaptic transmission, MAPKKK cascade, MyD88-independent toll-like receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, RNA metabolic process, nerve growth factor receptor signaling pathway, toll-like receptor 4 signaling pathway, insulin receptor signaling pathway, transcription from RNA polymerase I promoter, transcription initiation from RNA polymerase I promoter, muscle cell differentiation, nucleotide-binding oligomerization domain containing signaling pathway, platelet activation, epidermal growth factor receptor signaling pathway, Toll signaling pathway, blood coagulation.
REACTOME_COMPLEX: phospho-ERK-2 dimer [nucleoplasm] (REACT_5046), p38 MAPK : MAPKAPK2 or MAPKAPK3 [nucleoplasm] (REACT_22059), phospho-ERK-2:MEK2 [cytosol] (REACT_3199), MAP kinase p38 (Mg2+ cofactor) [cytosol] (REACT_12099), phospho p38:phospho MEF2 [nucleoplasm] (REACT_21504), AGER ligands:AGER:ERK [plasma membrane] (REACT_26296), p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (REACT_21610), pL1 (S1204, 1248):ERK2:clathrin-dynamin complex [endosome] (REACT_23286), pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (REACT_21750), MEK2:ERK-2 [cytosol] (REACT_5435), Activated PAR1:Beta-arrestin-1:Activated Src:ERK [plasma membrane] (REACT_24357), Activated PAR1:Beta-arrestin-1:Src:ERK [plasma membrane] (REACT_24135), phospho-p38 MAPK : phospho MAPKAPK2 or phospho MaPKAPK3 [cytosol] (REACT_21519), phospho-p38 MAPK : MAPKAPK2 or MaPKAPK3 [nucleoplasm] (REACT_21530), phospho-p38 MAPK : phospho MAPKAPK2 or phospho MaPKAPK3 [nucleoplasm] (REACT_21539), Activated PAR1:Beta-arrestin-2:Src:ERK [plasma membrane] (REACT_24842), phospho-ERK-2 dimer [cytosol] (REACT_3688), phospho-ERK-1 dimer [cytosol] (REACT_3932), phospho-ERK-1 dimer [nucleoplasm] (REACT_3152), Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol] (REACT_12273), Activated PAR1:Beta-arrestin-1:Activated Src:Activated ERK [plasma membrane] (REACT_24392), MEK1:ERK-1 [cytosol] (REACT_5539), phospho-ERK-1:MEK1 [cytosol] (REACT_2796).
REACTOME_PATHWAY: Toll Like Receptor 4 (TLR4) Cascade (REACT_109895), ADP signalling through P2Y purinoceptor 1 (REACT_19140), Thrombin signalling through proteinase activated receptors (PARs) (REACT_21384), Prolonged ERK activation events (REACT_12005), Regulation of mRNA Stability by Proteins that Bind AU-rich Elements (REACT_24994), SHC-mediated signalling (REACT_661), ERK/MAPK targets (REACT_31447), ERK activation (REACT_1482), ERK/MAPK targets (REACT_12599), MAP kinase activation in TLR cascade (REACT_82500), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (REACT_95028), G-protein mediated events (REACT_15526), Down-stream signal transduction (REACT_17025), MAP kinase activation in TLR cascade (REACT_21308), Toll Like Receptor 9 (TLR9) Cascade (REACT_9047), MyD88:Mal cascade initiated on plasma membrane (REACT_92018), NCAM signaling for neurite out-growth (REACT_18334), MyD88 dependent cascade initiated on endosome (REACT_25222), Toll Like Receptor TLR6:TLR2 Cascade (REACT_106218), activated TAK1 mediates p38 MAPK activation (REACT_21399), ERK1 activation (REACT_1391), Activated TLR4 signalling (REACT_90914), NGF signalling via TRKA from the plasma membrane (REACT_29880), Ca-dependent events (REACT_15307), NGF signalling via TRKA from the plasma membrane (REACT_12056), MyD88-independent cascade initiated on plasma membrane (REACT_99643), Signalling to ERKs (REACT_12058), Toll Like Receptor 10 (TLR10) Cascade (REACT_92313), Nuclear Events (kinase and transcription factor activation) (REACT_12433), ERKs are inactivated (REACT_12436), Toll Like Receptor 5 (TLR5) Cascade (REACT_9061), Hemostasis (REACT_604), IRS-related events (REACT_762), phospho-PLA2 pathway (REACT_15466), Metabolism of RNA (REACT_21257), Grb2 events in EGFR signaling (REACT_12606), RNA Polymerase I Promoter Opening (REACT_2232), Signaling by PDGF (REACT_16888), Toll Like Receptor 2 Cascade (REACT_109018), Platelet homeostasis (REACT_23876), Toll Receptor Cascades (REACT_91529), Activation of the AP-1 family of transcription factors (REACT_21326), Signaling by Insulin receptor (REACT_498), p38MAPK events (REACT_33936), MAPK targets/ Nuclear events mediated by MAP kinases (REACT_21328), Platelet sensitization by LDL (REACT_23879), ERK2 activation (REACT_1183), MyD88 cascade initiated on plasma membrane (REACT_27215), Immune System (REACT_6900), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (REACT_75913), CDO in myogenesis (REACT_21402), Signalling to RAS (REACT_12033), Signalling to RAS (REACT_79426), Toll Like Receptor 5 (TLR5) Cascade (REACT_30810), Signalling by NGF (REACT_11061), Insulin receptor signalling cascade (REACT_1195), Platelet activation triggers (REACT_622), Toll Like Receptor 9 (TLR9) Cascade (REACT_32391), Myogenesis (REACT_21303), Post NMDA receptor activation events (REACT_20593), Signal attenuation (REACT_508), activated TAK1 mediates p38 MAPK activation (REACT_87442), Toll Like Receptor TLR1:TLR2 Cascade (REACT_91838), Advanced glycosylation endproduct receptor signaling (REACT_25195), Opioid Signalling (REACT_15295), RSK activation (REACT_20510), Metabolism of mRNA (REACT_20605), Toll Like Receptor TLR6:TLR2 Cascade (REACT_8006), Toll Like Receptor TLR1:TLR2 Cascade (REACT_8005), Signal transduction by L1 (REACT_22272), NOD1/2 Signaling Pathway (REACT_75776), TRAF6 Mediated Induction of proinflammatory cytokines (REACT_34578), Toll Like Receptor 4 (TLR4) Cascade (REACT_6894), Signalling to ERKs (REACT_32318), Signalling by NGF (REACT_97378), RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription (REACT_21352), MyD88 cascade initiated on plasma membrane (REACT_81183), Toll Like Receptor 3 (TLR3) Cascade (REACT_99649), IRS-mediated signalling (REACT_332), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (REACT_25024), Nuclear Events (kinase and transcription factor activation) (REACT_90219), Immune System (REACT_105951), Formation of Platelet plug (REACT_20), Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (REACT_15370), Recycling pathway of L1 (REACT_22365), Axon guidance (REACT_18266), SOS-mediated signalling (REACT_524), RNA Polymerase I Promoter Clearance (REACT_1974), MyD88 dependent cascade initiated on endosome (REACT_87458), PLC beta mediated events (REACT_15426), Signalling to p38 via RIT and RIN (REACT_12077), Frs2-mediated activation (REACT_12076), Synaptic Transmission (REACT_13685), Shc events in EGFR signaling (REACT_12579), Transcription (REACT_1788), Signaling by EGFR (REACT_9417), ARMS-mediated activation (REACT_12002), L1CAM interactions (REACT_22205), RAF/MAP kinase cascade (REACT_634), Toll Like Receptor 7/8 (TLR7/8) Cascade (REACT_9020), Toll Like Receptor 10 (TLR10) Cascade (REACT_9027), Transmission across Chemical Synapses (REACT_13477), RNA Polymerase I Transcription (REACT_1309), Toll Like Receptor 3 (TLR3) Cascade (REACT_6783), TRAF6 Mediated Induction of proinflammatory cytokines (REACT_6782), Innate Immunity Signaling (REACT_88681), Toll Like Receptor 2 Cascade (REACT_7980), Toll Receptor Cascades (REACT_6966), MyD88:Mal cascade initiated on plasma membrane (REACT_6788), Platelet Activation (REACT_798), MAPK targets/ Nuclear events mediated by MAP kinases (REACT_78994), Activated TLR4 signalling (REACT_6890), NFkB and MAP kinases activation mediated by TLR4 signaling repertoire (REACT_34570), p38MAPK events (REACT_12065), SHC-related events (REACT_999), MyD88-independent cascade initiated on plasma membrane (REACT_6809), Destabilization of mRNA by KSRP (REACT_25042), Activation of NMDA receptor upon glutamate binding and postsynaptic events (REACT_20563), NFkB and MAP kinases activation mediated by TLR4 signaling repertoire (REACT_25281), CREB phosphorylation through the activation of Ras (REACT_20568), Innate Immunity Signaling (REACT_6802), Toll Like Receptor 7/8 (TLR7/8) Cascade (REACT_79068), Signal amplification (REACT_20524).
These properties come from kegg analysis
molecular_function: MAP kinase activity.
