Protein coding gene MELO3C011641
Accession: MELO3C011641
Name: MELO3C011641
Description: Similar to Gamma-secretase subunit APH1-like (Arabidopsis thaliana) (uniprot_sprot:sp|Q8L9G7|APH1_ARATH)
Properties
These properties come from reactome analysis
REACTOME_REACTION: NEXT4 is cleaved to produce NICD4 (REACT_965), NEXT3 is cleaved to produce NICD3 (REACT_1803), NEXT2 is cleaved to produce NICD2 (REACT_103855), gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (REACT_13710), gamma-secretase cleaves the p75NTR transmembrane domain (REACT_13609), NEXT1 is cleaved to produce NICD1 (REACT_1784), NEXT2 is cleaved to produce NICD2 (REACT_1306), NEXT1 is cleaved to produce NICD1 (REACT_34376).
biological_process: nerve growth factor receptor signaling pathway, Notch receptor processing, membrane protein intracellular domain proteolysis, apoptosis, induction of apoptosis by extracellular signals, Notch signaling pathway.
REACTOME_COMPLEX: gamma-secretase complex [plasma membrane] (REACT_5292).
REACTOME_PATHWAY: Signaling by Notch (REACT_78520), Cell death signalling via NRAGE, NRIF and NADE (REACT_13720), p75 NTR receptor-mediated signalling (REACT_13776), NRIF signals cell death from the nucleus (REACT_13643), Signalling by NGF (REACT_11061), A third proteolytic cleavage releases NICD (REACT_31981), Signaling by Notch (REACT_299), Regulated proteolysis of p75NTR (REACT_13443), A third proteolytic cleavage releases NICD (REACT_691).
These properties come from phylome analysis
molecular_function: endopeptidase activity, protein binding.
cellular_component: integral to plasma membrane, integral to membrane.
biological_process: Notch signaling pathway, positive regulation of catalytic activity, protein processing.
These properties come from blast2go analysis
molecular_function: protein binding.
cellular_component: integral to membrane.
biological_process: positive regulation of catalytic activity, protein processing.
