Protein coding gene MELO3C014021
Accession: MELO3C014021
Name: MELO3C014021
Description: Similar to Replication factor C subunit 4 (Schizosaccharomyces pombe) (uniprot_sprot:sp|O94449|RFC4_SCHPO)
Properties
These properties come from reactome analysis
REACTOME_REACTION: RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_93682), RFC dissociates after sliding clamp formation (REACT_94070), Loading of PCNA - Sliding Clamp Formation (REACT_1994), Recruitment of Rad17-RFC complex to DNA (REACT_6798), Loading of PCNA - Sliding Clamp Formation (REACT_84790), RFC binding displaces Pol Alpha (REACT_107444), RFC binding displaces Pol Alpha (REACT_95802), RFC binding displaces Pol Alpha (REACT_94779), Recruitment of the Rad9-Hus1-Rad1 complex to DNA (REACT_106382), RFC dissociates after sliding clamp formation (REACT_109827), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_83617), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_7967), RFC binding displaces Pol Alpha (REACT_100925), Loading of PCNA - Sliding Clamp Formation (REACT_77180), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_91661), Loading of PCNA - Sliding Clamp Formation (REACT_109854), Repair synthesis of patch ~27-30 bases long by DNA Pol Delta (REACT_465), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_8008), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_82014), RFC dissociates after sliding clamp formation (REACT_33911), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_8000), Recruitment of the Rad9-Hus1-Rad1 complex to DNA (REACT_107423), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_94930), RFC binding displaces Pol Alpha (REACT_90281), Loading of PCNA - Sliding Clamp Formation (REACT_89203), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_107682), Repair synthesis for gap-filling by DNA pol epsilon in TC-NER (REACT_677), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_95767), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_98653), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_108876), RFC binding displaces Pol Alpha (REACT_1871), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_83118), Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon (REACT_353), RFC dissociates after sliding clamp formation (REACT_351), RFC dissociates after sliding clamp formation (REACT_110721), Loading of PCNA - Sliding Clamp Formation (REACT_90918), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_96478), RFC binding displaces Pol Alpha on the C-strand of the telomere (REACT_101498), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_32714), Loading of PCNA - Sliding Clamp Formation (REACT_98979), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_96810), Recruitment of the Rad9-Hus1-Rad1 complex to DNA (REACT_6729), RFC dissociates after sliding clamp formation (REACT_108877), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_107049), RFC binding displaces Pol Alpha (REACT_29039), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_80757), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_30132), Repair synthesis for gap-filling by DNA pol delta in TC-NER (REACT_1196), RFC dissociates after sliding clamp formation (REACT_90684), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_32656).
biological_process: telomere maintenance via semi-conservative replication, cell cycle checkpoint, mitotic cell cycle, telomere maintenance via recombination, telomere maintenance, DNA strand elongation involved in DNA replication, nucleotide-excision repair, DNA repair, transcription-coupled nucleotide-excision repair, DNA replication, S phase of mitotic cell cycle, nucleotide-excision repair, DNA gap filling.
REACTOME_COMPLEX: Rad17-RFC complex bound to DNA [nucleoplasm] (REACT_7502), Rad17-RFC complex [nucleoplasm] (REACT_7804), RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (REACT_8208), RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (REACT_5474), RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (REACT_8972), RFC Heteropentamer [nucleoplasm] (REACT_4881), Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (REACT_7267), RFC Heteropentamer:RNA primer-DNA primer:origin duplex [nucleoplasm] (REACT_5241).
REACTOME_PATHWAY: Synthesis of DNA (REACT_29939), Chromosome Maintenance (REACT_22172), Leading Strand Synthesis (REACT_31129), Polymerase switching on the C-strand of the telomere (REACT_99801), Telomere C-strand (Lagging Strand) Synthesis (REACT_31770), DNA strand elongation (REACT_85667), Synthesis of DNA (REACT_29575), DNA Replication (REACT_383), Cell Cycle Checkpoints (REACT_109101), Polymerase switching (REACT_108196), Telomere C-strand (Lagging Strand) Synthesis (REACT_103027), Lagging Strand Synthesis (REACT_86713), G2/M Checkpoints (REACT_86653), Chromosome Maintenance (REACT_28158), Lagging Strand Synthesis (REACT_33812), Leading Strand Synthesis (REACT_88618), Telomere C-strand (Lagging Strand) Synthesis (REACT_91367), Leading Strand Synthesis (REACT_1838), Extension of Telomeres (REACT_85592), DNA Replication (REACT_101785), Polymerase switching on the C-strand of the telomere (REACT_29268), Cell Cycle Checkpoints (REACT_1538), DNA Replication (REACT_85544), Telomere Maintenance (REACT_7970), Polymerase switching on the C-strand of the telomere (REACT_104638), Transcription-coupled NER (TC-NER) (REACT_1628), Gap-filling DNA repair synthesis and ligation in GG-NER (REACT_1998), Synthesis of DNA (REACT_77553), Cell Cycle Checkpoints (REACT_90465), Repair synthesis of patch ~27-30 bases long by DNA polymerase (REACT_378), G2/M Checkpoints (REACT_98838), Telomere Maintenance (REACT_86038), Activation of ATR in response to replication stress (REACT_6769), DNA strand elongation (REACT_932), Extension of Telomeres (REACT_77975), Polymerase switching (REACT_31697), Synthesis of DNA (REACT_31294), Nucleotide Excision Repair (REACT_1826), Cell Cycle, Mitotic (REACT_96281), DNA Replication (REACT_101407), Leading Strand Synthesis (REACT_81940), Telomere C-strand (Lagging Strand) Synthesis (REACT_7961), Extension of Telomeres (REACT_79922), Cell Cycle, Mitotic (REACT_152), Lagging Strand Synthesis (REACT_107877), S Phase (REACT_78838), Gap-filling DNA repair synthesis and ligation in TC-NER (REACT_74), Chromosome Maintenance (REACT_94825), DNA strand elongation (REACT_107311), Extension of Telomeres (REACT_106742), Synthesis of DNA (REACT_2014), Activation of ATR in response to replication stress (REACT_108929), Polymerase switching (REACT_31686), Telomere Maintenance (REACT_87184), Lagging Strand Synthesis (REACT_104953), DNA Repair (REACT_216), Polymerase switching on the C-strand of the telomere (REACT_7987), Telomere Maintenance (REACT_80940), Polymerase switching on the C-strand of the telomere (REACT_95355), Activation of ATR in response to replication stress (REACT_97726), Polymerase switching on the C-strand of the telomere (REACT_101756), Repair synthesis for gap-filling by DNA polymerase in TC-NER (REACT_1993), Telomere Maintenance (REACT_78680), DNA strand elongation (REACT_76948), Cell Cycle, Mitotic (REACT_84794), Telomere C-strand (Lagging Strand) Synthesis (REACT_85706), DNA strand elongation (REACT_83094), Global Genomic NER (GG-NER) (REACT_2253), Cell Cycle, Mitotic (REACT_85950), Polymerase switching (REACT_94517), Polymerase switching (REACT_84976), Cell Cycle, Mitotic (REACT_108233), S Phase (REACT_89318), Lagging Strand Synthesis (REACT_76929), Lagging Strand Synthesis (REACT_107883), DNA strand elongation (REACT_84140), Polymerase switching (REACT_89784), S Phase (REACT_899), Telomere Maintenance (REACT_85782), DNA Replication (REACT_96557), Extension of Telomeres (REACT_81460), Synthesis of DNA (REACT_98237), S Phase (REACT_34043), Cell Cycle, Mitotic (REACT_53493), Leading Strand Synthesis (REACT_78985), S Phase (REACT_82813), Synthesis of DNA (REACT_29294), Leading Strand Synthesis (REACT_86413), Chromosome Maintenance (REACT_85555), Telomere C-strand (Lagging Strand) Synthesis (REACT_103769), Chromosome Maintenance (REACT_105513), Chromosome Maintenance (REACT_90690), DNA Replication (REACT_106731), Extension of Telomeres (REACT_8030), G2/M Checkpoints (REACT_828), S Phase (REACT_81914), Extension of Telomeres (REACT_78552), Telomere Maintenance (REACT_94707), DNA strand elongation (REACT_84115), S Phase (REACT_105829), Leading Strand Synthesis (REACT_79904), Chromosome Maintenance (REACT_94920), Lagging Strand Synthesis (REACT_312), DNA Replication (REACT_102375), Cell Cycle, Mitotic (REACT_90846), Polymerase switching (REACT_1792), Telomere C-strand (Lagging Strand) Synthesis (REACT_77927), Polymerase switching on the C-strand of the telomere (REACT_102170).
These properties come from blast2go analysis
molecular_function: ATP binding, protein binding, DNA-directed DNA polymerase activity, DNA clamp loader activity.
cellular_component: nuclear replication fork, Elg1 RFC-like complex, Rad17 RFC-like complex, cytosol, DNA replication factor C complex, nucleoplasm, nuclear chromatin.
biological_process: nucleotide-excision repair, DNA gap filling, leading strand elongation.
