Protein coding gene MELO3C018025

Accession: MELO3C018025

Name: MELO3C018025

Description: Similar to Tubulin alpha chain (Prunus dulcis) (uniprot_sprot:sp|P33629|TBA_PRUDU)


These properties come from blast2go analysis

molecular_function: GTP binding, structural molecule activity, GTPase activity.

cellular_component: microtubule.

biological_process: protein polymerization, microtubule-based movement.

These properties come from reactome analysis

REACTOME_REACTION: Loss of C-Nap-1 from centrosomes (REACT_15313), Recruitment of CDK11p58 to the centrosomes (REACT_15401), Transport of L1 from C-domain to P-domain (REACT_22136), alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B (REACT_16937), Translocation of NuMA to the centrosomes (REACT_15444), Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (REACT_15467), Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (REACT_16958), Docking of connexons into junctional, double-membrane spanning channels (REACT_10108), Insertion of connexons into the plasma membrane resulting in the formation of hemi-channels (REACT_10004), alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E (REACT_17027), Association of NuMA with microtubules (REACT_15294), Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (REACT_17060), Kinetochore capture of astral microtubules (REACT_14798), alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (REACT_16900), Reinsertion of L1 into the plasma membrane (REACT_22298), Dissociation of Phospho-Nlp from the centrosome (REACT_15440), ADP is exchanged for ATP in the (ADP:CCT/TriC):tubulin complex (REACT_16909), Recruitment of Plk1 to centrosomes (REACT_15470), Actin/tubulin:prefoldin complex associates with CCT/TriC (REACT_16961), Association of Golgi transport vesicles with microtubules (REACT_10011), Release of platelet cytosolic components (REACT_21347), unfolded actin/tubulin associates with prefoldin (REACT_16892), Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (REACT_17032), Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (REACT_17016), Kinesins bind microtubules (REACT_25309), Plk1-mediated phosphorylation of Nlp (REACT_15386).

biological_process: platelet activation, mitotic prometaphase, post-chaperonin tubulin folding pathway, cellular protein metabolic process, mitotic cell cycle, gap junction assembly, platelet degranulation, cellular membrane organization, 'de novo' posttranslational protein folding, axon guidance, blood coagulation, M phase of mitotic cell cycle, G2/M transition of mitotic cell cycle, protein folding, microtubule-based movement.

REACTOME_COMPLEX: Mature centrosomes enriched in gamma-TURC complexes [cytosol] (REACT_15605), Cofactor B:GTP-alpha tubulin [cytosol] (REACT_17838), NuMA-bound microtubules [cytosol] (REACT_18043), alpha tubulin:GTP [cytosol] (REACT_10160), Kinesins:microtubule [cytosol] (REACT_26291), beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (REACT_17144), centrosome-associated NuMA [cytosol] (REACT_15920), CCT/TriC(ADP)-associated non-native tubulin [cytosol] (REACT_17102), Centrosomes containing recruited CDK11p58 [cytosol] (REACT_17657), beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (REACT_17650), GTP-alpha-tubulin folding intermediate [cytosol] (REACT_17776), centrosome containing phosphorylated Nlp [cytosol] (REACT_17093), actin/tubulin-bound CCT/TriC(ADP) [cytosol] (REACT_17195), centrosome-nucleated microtubules [cytosol] (REACT_16122), Docked Cx43-containing transport vesicles [plasma membrane] (REACT_10422), alpha-beta tubulin dimer [cytosol] (REACT_10241), cNAP-1 depleted centrosome [cytosol] (REACT_17186), Nlp-depleted centrosome [cytosol] (REACT_18075), Prefoldin-associated actin/tubulin [cytosol] (REACT_18141), native alpha tubulin-GTP [cytosol] (REACT_17521), connexons in Golgi transport vesicle docked to microtubules [cytosol] (REACT_10450), CCT/TriC(ATP):unfolded tubulin complex [cytosol] (REACT_17889), alpha-beta heterodimer [cytosol] (REACT_18200), Cofactor E:GTP-alpha tubulin folding [cytosol] (REACT_17474), Microtubule-bound kinetochore [cytosol] (REACT_15175), Centrosome associated Plk1 [cytosol] (REACT_18209), tubulin-GTP folding intermediate [cytosol] (REACT_17885), AP2 clathrin:L1:KIF4:microtubule [cytosol] (REACT_23331), centrosome [cytosol] (REACT_15979).

REACTOME_PATHWAY: M Phase (REACT_910), Recycling pathway of L1 (REACT_22365), Prefoldin mediated transfer of substrate to CCT/TriC (REACT_16936), Hemostasis (REACT_604), DNA Replication (REACT_383), Kinesins (REACT_25201), Protein folding (REACT_16952), Gap junction trafficking and regulation (REACT_9480), Formation of tubulin folding intermediates by CCT/TriC (REACT_16956), G2/M Transition (REACT_2203), Gap junction trafficking (REACT_9411), Mitotic Prometaphase (REACT_682), Cell Cycle, Mitotic (REACT_152), Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (REACT_17029), Recruitment of mitotic centrosome proteins and complexes (REACT_15296), Chaperonin-mediated protein folding (REACT_17004), Mitotic M-M/G1 phases (REACT_21300), Transport of connexons to the plasma membrane (REACT_11050), L1CAM interactions (REACT_22205), Platelet degranulation (REACT_318), Membrane Trafficking (REACT_11123), Loss of Nlp from mitotic centrosomes (REACT_15364), Mitotic G2-G2/M phases (REACT_21391), Loss of proteins required for interphase microtubule organization from the centrosome (REACT_15451), Post-chaperonin tubulin folding pathway (REACT_16967), Platelet Activation (REACT_798), Centrosome maturation (REACT_15479), Recruitment of NuMA to mitotic centrosomes (REACT_15510), Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (REACT_11039), Gap junction assembly (REACT_9509), Factors involved in megakaryocyte development and platelet production (REACT_24970), Response to elevated platelet cytosolic Ca2+ (REACT_1280), Metabolism of proteins (REACT_17015), Formation of Platelet plug (REACT_20), Axon guidance (REACT_18266).

These properties come from kegg analysis

cellular_component: microtubule.


Located in CM3.5_scaffold00031 from 3805407 to 3808190.

Related features