Protein coding gene MELO3C022371
Accession: MELO3C022371
Name: MELO3C022371
Description: Similar to A/G-specific adenine DNA glycosylase (Mus musculus) (uniprot_sprot:sp|Q99P21|MUTYH_MOUSE)
Properties
These properties come from blast2go analysis
molecular_function: iron-sulfur cluster binding, hydrolase activity, acting on glycosyl bonds.
cellular_component: membrane, mitochondrion.
biological_process: DNA repair.
These properties come from reactome analysis
REACTOME_REACTION: MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine (REACT_109570), Cleavage 8-oxo guanine by MYH glycosylase (REACT_28786), MYH glycosylase mediated recognition and binding of an adenine opposite to an 8-oxo guanine (REACT_313), Displacement of MYH glycosylase by APE1 at the AP site (REACT_102780), Cleavage 8-oxo guanine by MYH glycosylase (REACT_818), Displacement of MYH glycosylase by APE1 at the AP site (REACT_1894).
biological_process: base-excision repair, AP site formation, depurination, base-excision repair, DNA repair.
REACTOME_COMPLEX: MYH glycosylase:adenine complex [nucleoplasm] (REACT_2660), DNA containing an MYH-bound apurinic/apyrimidinic site [nucleoplasm] (REACT_3901).
REACTOME_PATHWAY: Displacement of DNA glycosylase by APE1 (REACT_78785), Depurination (REACT_626), Resolution of AP sites via the single-nucleotide replacement pathway (REACT_105952), Base-free sugar-phosphate removal via the single-nucleotide replacement pathway (REACT_109512), Depurination (REACT_99931), Base Excision Repair (REACT_1104), Removal of DNA patch containing abasic residue (REACT_2192), Cleavage of the damaged purine (REACT_93169), Displacement of DNA glycosylase by APE1 (REACT_1064), Base-Excision Repair, AP Site Formation (REACT_804), Removal of DNA patch containing abasic residue (REACT_28914), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_104846), Recognition and association of DNA glycosylase with site containing an affected purine (REACT_2176), Cleavage of the damaged purine (REACT_1729), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_1128), Resolution of Abasic Sites (AP sites) (REACT_1893), DNA Repair (REACT_82907), Base-Excision Repair, AP Site Formation (REACT_33245), Recognition and association of DNA glycosylase with site containing an affected purine (REACT_88079), Base-free sugar-phosphate removal via the single-nucleotide replacement pathway (REACT_1357), DNA Repair (REACT_216), Base Excision Repair (REACT_99288), Resolution of Abasic Sites (AP sites) (REACT_100019), Resolution of AP sites via the single-nucleotide replacement pathway (REACT_933).
These properties come from phylome analysis
molecular_function: 4 iron, 4 sulfur cluster binding, metal ion binding, MutSalpha complex binding, DNA N-glycosylase activity, hydrolase activity, endonuclease activity, DNA binding.
cellular_component: nucleoplasm, intracellular.
biological_process: depurination, mismatch repair, base-excision repair.
These properties come from kegg analysis
KEGG_ORTHOLOGS: A/G-specific adenine glycosylase [EC:3.2.2.-] (K03575).
COG: A/G-specific DNA glycosylase (COG1194).
