Protein coding gene MELO3C025879
Accession: MELO3C025879
Name: MELO3C025879
Description: Similar to Proliferating cell nuclear antigen (Nicotiana tabacum) (uniprot_sprot:sp|O82797|PCNA_TOBAC)
Properties
These properties come from blast2go analysis
molecular_function: DNA polymerase processivity factor activity, protein binding, DNA binding.
cellular_component: PCNA complex, nucleus.
biological_process: regulation of DNA replication.
These properties come from reactome analysis
REACTOME_REACTION: Loading of PCNA - Sliding Clamp Formation (REACT_1994), RPA binds to the Flap (REACT_2026), Removal of remaining Flap (REACT_2024), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_82014), Formation of C-strand Okazaki fragments (REACT_8029), Recruitment of Dna2 endonuclease (REACT_79480), Removal of remaining Flap from the C-strand (REACT_29736), Formation of Okazaki fragments (REACT_104153), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_94930), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_96810), Formation of the Flap Intermediate on the C-strand (REACT_7973), Formation of Okazaki fragments (REACT_109069), Formation of Processive Complex (REACT_82155), RPA binds to the Flap on the C-strand (REACT_7949), RFC dissociates after sliding clamp formation (REACT_109827), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_7967), Removal of remaining Flap from the C-strand (REACT_97146), Loading of PCNA - Sliding Clamp Formation (REACT_77180), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_30132), Formation of Processive Complex (REACT_1009), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_91661), Loading of PCNA - Sliding Clamp Formation (REACT_109854), Repair synthesis of patch ~27-30 bases long by DNA Pol Delta (REACT_465), Disassociation of Processive Complex and Completed Telomere End (REACT_85317), Formation of the Flap Intermediate (REACT_1572), Formation of the Flap Intermediate (REACT_33401), Interaction between FEN1 and PCNA (REACT_1288), RFC dissociates after sliding clamp formation (REACT_33911), Recruitment of Dna2 endonuclease (REACT_103547), Interaction between FEN1 and PCNA (REACT_105716), Formation of Okazaki fragments (REACT_1024), RFC dissociates after sliding clamp formation (REACT_110721), Formation of the Flap Intermediate on the C-strand (REACT_97574), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_8000), Removal of remaining Flap (REACT_79626), Joining of adjacent Okazaki fragments of the C-strand (REACT_7994), RFC dissociates after sliding clamp formation (REACT_108877), Formation of Processive Complex on the C-strand of the telomere (REACT_77820), Formation of Processive Complex on the C-strand of the telomere (REACT_108058), Recruitment of Dna2 endonuclease to the C strand (REACT_79008), Interaction between FEN1 and PCNA (REACT_85261), Formation of the Flap Intermediate (REACT_78319), Interaction between FEN1 and PCNA (REACT_77342), Loading of PCNA - Sliding Clamp Formation (REACT_89203), Disassociation of Processive Complex and Completed Telomere End (REACT_86194), Repair synthesis for gap-filling by DNA pol epsilon in TC-NER (REACT_677), Formation of C-strand Okazaki fragments (REACT_77128), Loading of PCNA - Sliding Clamp Formation (REACT_84790), Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (REACT_7955), Disassociation of Processive Complex and Completed Telomere End (REACT_7954), Formation of Processive Complex on the C-strand of the telomere (REACT_7979), Formation of Processive Complex (REACT_87660), RFC dissociates after sliding clamp formation (REACT_94070), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_83617), Joining of adjacent Okazaki fragments of the C-strand (REACT_94317), Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon (REACT_353), RFC dissociates after sliding clamp formation (REACT_351), Formation of the Flap Intermediate on the C-strand (REACT_28735), Joining of adjacent Okazaki fragments of the C-strand (REACT_106919), Removal of remaining Flap from the C-strand (REACT_7975), Loading of PCNA - Sliding Clamp Formation (REACT_90918), Removal of remaining Flap (REACT_96177), Removal of RNA primer and dissociation of RPA and Dna2 (REACT_315), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_96478), Formation of C-strand Okazaki fragments (REACT_93535), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_32714), Loading of PCNA - Sliding Clamp Formation (REACT_98979), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_95767), Interaction between FEN1 and PCNA (REACT_84857), Interaction between FEN1 and PCNA (REACT_79925), Recruitment of Dna2 endonuclease (REACT_1278), Interaction between FEN1 and PCNA (REACT_78772), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_107049), Recruitment of Dna2 endonuclease to the C strand (REACT_30357), RFC dissociates after sliding clamp formation on the C-strand of the telomere (REACT_80757), Recruitment of Dna2 endonuclease to the C strand (REACT_8015), Repair synthesis for gap-filling by DNA pol delta in TC-NER (REACT_1196), RFC dissociates after sliding clamp formation (REACT_90684), Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (REACT_32656).
biological_process: telomere maintenance via semi-conservative replication, mitotic cell cycle, base-excision repair, telomere maintenance via recombination, telomere maintenance, nucleotide-excision repair, DNA gap filling, DNA strand elongation involved in DNA replication, nucleotide-excision repair, DNA repair, transcription-coupled nucleotide-excision repair, S phase of mitotic cell cycle.
REACTOME_COMPLEX: Processive complex [nucleoplasm] (REACT_3120), Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (REACT_8363), PCNA homotrimer [nucleoplasm] (REACT_2542), Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (REACT_8468), Processive complex:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (REACT_4371), Processive complex loaded on telomere [nucleoplasm] (REACT_8041), RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer [nucleoplasm] (REACT_5474), RNA primer-DNA primer:origin duplex:PCNA [nucleoplasm] (REACT_4810), Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (REACT_4699), Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (REACT_8837), Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (REACT_8321), RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (REACT_8843), Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] (REACT_4338), Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (REACT_8956), Processive complex:Okazaki fragment:Flap [nucleoplasm] (REACT_4984), FEN1:PCNA complex [nucleoplasm] (REACT_4419), Processive complex:Okazaki fragment complex [nucleoplasm] (REACT_5537), Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (REACT_8309), Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (REACT_8541), RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (REACT_8208), Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm] (REACT_3597).
REACTOME_PATHWAY: Synthesis of DNA (REACT_29939), Chromosome Maintenance (REACT_22172), DNA Repair (REACT_107752), Leading Strand Synthesis (REACT_31129), Telomere C-strand (Lagging Strand) Synthesis (REACT_31770), Processive synthesis on the C-strand of the telomere (REACT_82465), DNA strand elongation (REACT_85667), Synthesis of DNA (REACT_29575), DNA Replication (REACT_383), Polymerase switching (REACT_108196), Removal of DNA patch containing abasic residue (REACT_95848), Telomere C-strand (Lagging Strand) Synthesis (REACT_7961), Lagging Strand Synthesis (REACT_86713), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_94766), DNA Repair (REACT_88201), Chromosome Maintenance (REACT_28158), Lagging Strand Synthesis (REACT_33812), Leading Strand Synthesis (REACT_88618), Telomere C-strand (Lagging Strand) Synthesis (REACT_91367), Leading Strand Synthesis (REACT_1838), Gap-filling DNA repair synthesis and ligation in TC-NER (REACT_74), Removal of DNA patch containing abasic residue (REACT_28914), Extension of Telomeres (REACT_85592), Resolution of Abasic Sites (AP sites) (REACT_108165), Synthesis of DNA (REACT_77553), Polymerase switching on the C-strand of the telomere (REACT_29268), Polymerase switching on the C-strand of the telomere (REACT_99801), Telomere Maintenance (REACT_7970), Polymerase switching on the C-strand of the telomere (REACT_104638), Transcription-coupled NER (TC-NER) (REACT_1628), Gap-filling DNA repair synthesis and ligation in GG-NER (REACT_1998), DNA Replication (REACT_101785), DNA Repair (REACT_93704), Processive synthesis on the C-strand of the telomere (REACT_108285), Repair synthesis of patch ~27-30 bases long by DNA polymerase (REACT_378), Base Excision Repair (REACT_99288), Resolution of Abasic Sites (AP sites) (REACT_100019), Telomere Maintenance (REACT_86038), DNA strand elongation (REACT_932), DNA strand elongation (REACT_84115), Extension of Telomeres (REACT_77975), Polymerase switching (REACT_31697), DNA Repair (REACT_107446), Removal of DNA patch containing abasic residue (REACT_30076), Nucleotide Excision Repair (REACT_1826), Telomere C-strand (Lagging Strand) Synthesis (REACT_103027), Removal of the Flap Intermediate from the C-strand (REACT_102881), Cell Cycle, Mitotic (REACT_96281), DNA Replication (REACT_101407), Leading Strand Synthesis (REACT_81940), Base Excision Repair (REACT_1104), Processive synthesis on the lagging strand (REACT_79693), Lagging Strand Synthesis (REACT_107877), S Phase (REACT_78838), Removal of the Flap Intermediate (REACT_70), Removal of the Flap Intermediate from the C-strand (REACT_87982), Base Excision Repair (REACT_83441), Chromosome Maintenance (REACT_94825), DNA strand elongation (REACT_83094), Base Excision Repair (REACT_34413), Extension of Telomeres (REACT_106742), Synthesis of DNA (REACT_2014), Removal of the Flap Intermediate (REACT_95112), Polymerase switching (REACT_31686), Removal of DNA patch containing abasic residue (REACT_2192), S Phase (REACT_899), Lagging Strand Synthesis (REACT_104953), DNA Repair (REACT_216), Telomere Maintenance (REACT_85782), Polymerase switching on the C-strand of the telomere (REACT_7987), Telomere Maintenance (REACT_80940), Removal of DNA patch containing abasic residue (REACT_107721), Polymerase switching on the C-strand of the telomere (REACT_101756), Polymerase switching on the C-strand of the telomere (REACT_95355), Repair synthesis for gap-filling by DNA polymerase in TC-NER (REACT_1993), Telomere Maintenance (REACT_78680), DNA strand elongation (REACT_76948), Cell Cycle, Mitotic (REACT_84794), Telomere C-strand (Lagging Strand) Synthesis (REACT_85706), Resolution of Abasic Sites (AP sites) (REACT_93333), DNA Repair (REACT_91442), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_93137), DNA strand elongation (REACT_107311), Global Genomic NER (GG-NER) (REACT_2253), Removal of the Flap Intermediate from the C-strand (REACT_7999), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_97554), Synthesis of DNA (REACT_31294), Cell Cycle, Mitotic (REACT_85950), Polymerase switching (REACT_94517), Resolution of Abasic Sites (AP sites) (REACT_93432), Polymerase switching (REACT_84976), Processive synthesis on the lagging strand (REACT_80193), Cell Cycle, Mitotic (REACT_108233), S Phase (REACT_89318), Resolution of Abasic Sites (AP sites) (REACT_82921), Lagging Strand Synthesis (REACT_76929), Processive synthesis on the lagging strand (REACT_1385), Cell Cycle, Mitotic (REACT_152), DNA strand elongation (REACT_84140), Polymerase switching (REACT_89784), Telomere Maintenance (REACT_87184), DNA Replication (REACT_85544), DNA Replication (REACT_96557), Extension of Telomeres (REACT_81460), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_28683), Synthesis of DNA (REACT_98237), S Phase (REACT_34043), Base Excision Repair (REACT_107274), Cell Cycle, Mitotic (REACT_53493), Processive synthesis on the C-strand of the telomere (REACT_8027), Leading Strand Synthesis (REACT_78985), S Phase (REACT_82813), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_99623), Synthesis of DNA (REACT_29294), Leading Strand Synthesis (REACT_86413), Removal of DNA patch containing abasic residue (REACT_31716), Chromosome Maintenance (REACT_85555), Telomere C-strand (Lagging Strand) Synthesis (REACT_103769), Chromosome Maintenance (REACT_105513), Chromosome Maintenance (REACT_90690), DNA Replication (REACT_106731), Extension of Telomeres (REACT_8030), Extension of Telomeres (REACT_79922), Lagging Strand Synthesis (REACT_107883), S Phase (REACT_81914), Extension of Telomeres (REACT_78552), Telomere Maintenance (REACT_94707), Base Excision Repair (REACT_28342), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_104846), Resolution of AP sites via the multiple-nucleotide patch replacement pathway (REACT_1128), S Phase (REACT_105829), Leading Strand Synthesis (REACT_79904), Resolution of Abasic Sites (AP sites) (REACT_1893), Base Excision Repair (REACT_105824), DNA Repair (REACT_82907), Removal of the Flap Intermediate (REACT_106604), Chromosome Maintenance (REACT_94920), Resolution of Abasic Sites (AP sites) (REACT_103045), Lagging Strand Synthesis (REACT_312), DNA Replication (REACT_102375), Cell Cycle, Mitotic (REACT_90846), Removal of DNA patch containing abasic residue (REACT_98821), Polymerase switching (REACT_1792), Telomere C-strand (Lagging Strand) Synthesis (REACT_77927), Polymerase switching on the C-strand of the telomere (REACT_102170).
These properties come from phylome analysis
molecular_function: DNA polymerase processivity factor activity, DNA binding.
cellular_component: PCNA complex, nucleus.
biological_process: DNA replication, regulation of DNA replication.
These properties come from kegg analysis
COG: DNA polymerase sliding clamp subunit (PCNA homolog) (COG0592).
